Exercise and Cancer-Related Fatigue Syndrome

CRF is the most frequently reported symptom affecting up to 90% of cancer patients. CRF is distinguishable from normal tiredness in that CRF symptoms are severe, distressing, and are not relieved by rest or sleep. While the mechanisms and contributing factors that lead to CRF are unclear, good evidence exists for promoting exercise as an intervention to combat CRF. Currently, more than 20 RCTs have examined the effects of exercise on CRF scores. Despite methodological limitations and small sample sizes, the evidence suggests that exercise can improve CRF both during and after cancer treatments. Current guidelines for exercise prescription in this population recommend a progressive aerobic exercise program of 20–30 min.session–1, 3–5 days.week–1 at a moderate intensity of 60–80% of MHR. Further research is needed that examines potential mechanisms by which exercise influences symptoms of CRF. 2.